4307 Role of Pre-pregnancy Uterine Natural Killer Cells in Human Embryo Implantation
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چکیده
منابع مشابه
O-8: Critical Role of Hyaluronan System in Pre-Implantation Embryo Development and Establishment of Pregnancy
Background: Hyaluronan (HA) is a structural component of extracellular matrix synthesised by HA synthases HAS1-3, which produce HA of different molecular sizes with distinct biological functions associated with reproductive processes. Hyaluronidase (HYAL) cleaves the HA into biologically active small fragments which are known to regulate cell proliferation through CD44 receptor signaling. HA is...
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Background: Pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Killer cells population in the pregnant mice that needs to be investigated. Objective: The aim of this study was to determine the effect of the ethanolic extract of the Salvia officinalis on the uterine Natural Kill...
متن کاملHuman pre-implantation embryo development.
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and g...
متن کاملlow-dose aspirin and uterine natural killer cells in mice at day seven of pregnancy
results the ovarian hormones level showed a significant difference between the experimental and control groups (p < 0.05). furthermore, the unk cell population showed a significant difference between the two groups (p < 0.05). conclusions increased ovarian hormones due to low-dose aspirin administration resulted in decline in the unk cells number, which may be effective in successful pregnancy....
متن کاملUterine natural killer cells initiate spiral artery remodeling in human pregnancy.
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are "trophoblast-independent" and "trophoblast-dependent" stages. Uterine natural killer (uNK) cells ...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Science
سال: 2020
ISSN: 2059-8661
DOI: 10.1017/cts.2020.316